• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗原与Ia的相互作用及抗原的蛋白水解加工：抗原的结构决定其对主要组织相容性复合体A或E分子的限制性。

Antigen-Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecule of the major histocompatibility complex.

作者信息

Puri J, Lonai P, Friedman V

出版信息

Eur J Immunol. 1986 Sep;16(9):1093-7. doi: 10.1002/eji.1830160911.

DOI:10.1002/eji.1830160911
PMID:2428626
Abstract

The effect of a protease inhibitor, leupeptin, on the presentation of hen egg lysozyme (HEL) to cloned T cells was investigated. We found that leupeptin-sensitive thiol proteases are apparently less involved when HEL is presented by the I-Ad molecule, than when it is presented by the I-Ed molecule. This selectivity was more of a function of the antigen than that of the Ia molecule because presentation of denatured or fragmented HEL was not sensitive to leupeptin whereas antigen presentation to a number of I-A-restricted T cell clones specific to other antigens was sensitive to leupeptin. These data demonstrate that the particular combination of major histocompatibility complex/nominal antigen recognized by a certain T cell clone may require processing of the antigen molecule through a certain group of proteases and that other combinations are independent of that particular processing pathway. Furthermore, there is a preference for a certain type of processing depending on the Ia molecule involved.

摘要

研究了蛋白酶抑制剂亮抑蛋白酶肽对鸡卵溶菌酶（HEL）向克隆T细胞呈递的影响。我们发现，当HEL由I-Ad分子呈递时，亮抑蛋白酶肽敏感的巯基蛋白酶的参与程度明显低于由I-Ed分子呈递时。这种选择性更多地是抗原的功能，而非Ia分子的功能，因为变性或片段化的HEL的呈递对亮抑蛋白酶肽不敏感，而向许多针对其他抗原的I-A限制性T细胞克隆的抗原呈递对亮抑蛋白酶肽敏感。这些数据表明，特定T细胞克隆识别的主要组织相容性复合体/名义抗原的特定组合可能需要通过特定的一组蛋白酶对抗原分子进行加工，而其他组合则独立于该特定加工途径。此外，根据所涉及的Ia分子，存在对特定类型加工的偏好。

相似文献

1
Antigen-Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecule of the major histocompatibility complex.抗原与Ia的相互作用及抗原的蛋白水解加工：抗原的结构决定其对主要组织相容性复合体A或E分子的限制性。
Eur J Immunol. 1986 Sep;16(9):1093-7. doi: 10.1002/eji.1830160911.
2
Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells.在内质网中保留或呈分泌形式的内源性合成鸡卵清溶菌酶的加工过程，会产生一组类似但不完全相同的表位，这些表位可被Ⅱ类限制性T细胞识别。
J Immunol. 1993 Oct 1;151(7):3576-86.
3
Constraints in antigen processing result in unresponsiveness to a T cell epitope of hen egg lysozyme in C57BL/6 mice.抗原加工过程中的限制导致C57BL/6小鼠对鸡蛋溶菌酶的T细胞表位无反应性。
Eur J Immunol. 1992 Mar;22(3):775-82. doi: 10.1002/eji.1830220322.
4
Inhibition by chloroquine of the class II major histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding T cell.氯喹对内源性抗原的II类主要组织相容性复合体限制提呈的抑制作用，因抗原呈递细胞的细胞来源、T细胞表位的性质以及应答性T细胞的不同而有所差异。
Immunology. 1993 Dec;80(4):566-73.
5
Generation of hen egg lysozyme-specific and major histocompatibility complex class I-restricted cytolytic T lymphocytes: recognition of cytosolic and secreted antigen expressed by transfected cells.鸡卵溶菌酶特异性及主要组织相容性复合体I类分子限制性细胞毒性T淋巴细胞的产生：对转染细胞表达的胞质和分泌抗原的识别
Eur J Immunol. 1990 Oct;20(10):2325-32. doi: 10.1002/eji.1830201023.
6
The expressed T cell repertoire is hierarchical: the precise focus of lysozyme-specific T cell clones is dependent upon the structure of the immunogen.表达的T细胞库具有层次结构：溶菌酶特异性T细胞克隆的精确靶向取决于免疫原的结构。
J Mol Cell Immunol. 1984;1(6):369-79.
7
The extracellular domains of MHC class II molecules determine their processing requirements for antigen presentation.MHC II类分子的胞外结构域决定了其抗原呈递的加工要求。
J Immunol. 1990 Apr 15;144(8):2915-24.
8
Cytosolic targeting of hen egg lysozyme gives rise to a short-lived protein presented by class I but not class II major histocompatibility complex molecules.将鸡卵溶菌酶靶向定位于胞质溶胶会产生一种由I类而非II类主要组织相容性复合体分子呈递的短寿命蛋白质。
Eur J Immunol. 1991 Mar;21(3):761-9. doi: 10.1002/eji.1830210332.
9
Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule.小鼠II类分子限制性T细胞克隆对流感病毒血凝素合成肽的精细特异性。抗原与T细胞及Ia分子相互作用的异质性。
J Immunol. 1988 Jun 15;140(12):4083-90.
10
Inhibition of T cell response with peptides is influenced by both peptide-binding specificity of major histocompatibility complex molecules and susceptibility of T cells to blocking.肽对T细胞反应的抑制受到主要组织相容性复合体分子的肽结合特异性和T细胞对阻断的敏感性的影响。
Eur J Immunol. 1989 Jun;19(6):1071-7. doi: 10.1002/eji.1830190617.

引用本文的文献

1
Role for intracellular proteases in the processing and transport of class II HLA antigens.细胞内蛋白酶在II类人 HLA 抗原的加工和运输中的作用。
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3975-9. doi: 10.1073/pnas.85.11.3975.
2
Direct binding of a synthetic multichain polypeptide to class II major histocompatibility complex molecules on antigen-presenting cells and stimulation of a specific T-cell line require processing of the polypeptide.合成多链多肽与抗原呈递细胞上的II类主要组织相容性复合体分子的直接结合以及对特定T细胞系的刺激需要该多肽的加工处理。
Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9738-42. doi: 10.1073/pnas.88.21.9738.
3
The endo/lysosomal protease cathepsin B is able to process conalbumin fragments for presentation to T cells.
内质网/溶酶体蛋白酶组织蛋白酶B能够处理伴清蛋白片段，以呈递给T细胞。
Immunology. 1991 Nov;74(3):393-8.