白细胞介素-13 基因与中国南方汉族人群慢性阻塞性肺疾病发病的相关性：一项病例对照研究。

Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study.

机构信息

Department of Respiratory Disease, Huashan Hospital, Fudan University, Shanghai 200040, China.

出版信息

Chin Med J (Engl). 2013 Dec;126(23):4403-8.

Abstract

BACKGROUND

Interleukin-13 (IL-13) has been implicated to be responsible for recruitment of inflammatory cells from the blood to the lung, regulation of matrix metalloproteinase and induction of mucin production and secretion in chronic obstructive pulmonary disease (COPD). We determined plasma IL-13 levels in patients with COPD and investigated its association with common polymorphisms of IL-13 gene in a case-control study.

METHODS

We genotyped 160 cases and 175 control subjects in a local hospital using Mass-Array(TM) Technology Platform then tested the association of four SNPs in IL-13 (rs1295685, rs1800925, rs1881457, rs20541) with COPD, and then determined plasma IL-13 levels in patients with COPD and controls.

RESULTS

Association was found between IL-13 gene SNPs (rs20541 and rs1800925) and an increased risk of COPD. By linkage disequilibrium (LD) analysis, two blocks (rs1881457 and rs1800925; rs20541 and rs1295685) were found. The risk of COPD was found associated with the IL-13 gene polymorphism among southern Chinese Han population. Plasma IL-13 level was increased in COPD patients compared with controls.

CONCLUSIONS

The polymorphism of the IL-13 gene is associated with an increased risk of COPD in southern Chinese Han population. Plasma IL-13 levels were found elevated in patients with COPD.

摘要

背景

白细胞介素-13（IL-13）被认为是导致炎症细胞从血液向肺部募集、调节基质金属蛋白酶以及诱导慢性阻塞性肺疾病（COPD）中粘蛋白产生和分泌的原因。我们在一项病例对照研究中测定了 COPD 患者的血浆 IL-13 水平，并研究了其与 IL-13 基因常见多态性的关系。

方法

我们使用 Mass-Array（TM）技术平台对当地医院的 160 例病例和 175 例对照进行了基因分型，然后测试了 IL-13 中四个 SNP（rs1295685、rs1800925、rs1881457、rs20541）与 COPD 的关联，然后测定了 COPD 患者和对照组的血浆 IL-13 水平。

结果

发现 IL-13 基因 SNP（rs20541 和 rs1800925）与 COPD 风险增加有关。通过连锁不平衡（LD）分析，发现了两个块（rs1881457 和 rs1800925；rs20541 和 rs1295685）。在汉族南方人群中，发现 IL-13 基因多态性与 COPD 风险相关。与对照组相比，COPD 患者的血浆 IL-13 水平升高。