Department of Medicine, New York University School of Medicine/New York University Cancer Center, 240 East 38th Street, New York, NY 10016, USA.
Hematol Oncol Clin North Am. 2014 Feb;28(1):105-22. doi: 10.1016/j.hoc.2013.10.004.
Although most patients with Hodgkin lymphoma (HL) are cured with primary therapy, patients with primary refractory disease or relapse after initial treatment have poor outcomes and represent an unmet medical need. Recent advances in unraveling the biology of HL have yielded a plethora of novel targeted therapies. This review provides an overview of the data behind the hype generated by these advances and addresses the question of whether or not clinically these targeted therapies offer hope for patients with HL.
虽然大多数霍奇金淋巴瘤(HL)患者可以通过初始治疗治愈,但原发性难治性疾病或初始治疗后复发的患者预后较差,存在未满足的医疗需求。解析 HL 生物学的最新进展产生了大量新型靶向治疗方法。本综述概述了这些进展所引发的热潮背后的数据,并探讨了这些靶向治疗方法是否为 HL 患者带来了临床希望这一问题。