Huang Chen, Zhao Guimin, Wang Lianjing, Zhang Huichao, Wu Xiaolin, Zhang Mingzeng, Ma Ruijuan, Wang Ling, Liu Yueping, Liu Lihong
Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Department of Inspection, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Oncol Lett. 2016 Jun;11(6):4139-4143. doi: 10.3892/ol.2016.4503. Epub 2016 Apr 27.
Hodgkin's lymphoma (HL) is a type of hematological neoplasm that generally appears alone, with a low incidence. The majority of cases histopathologically present as B-cell lymphoma. Multiple myeloma (MM) is defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin (Ig). The coexistence of HL and MM is rare, however, the present study reports such a case. On May 31, 2012, a 45-year-old man was diagnosed with HL, stage III, 31 months ago. At the same time, computed tomography and magnetic resonance imaging showed osteolytic lesions, a significant increase in IgA λ chains, and multiple myeloma cells on bone marrow aspiration. Following 8 cycles of chemotherapy, the patient received maintenance treatment with thalidomide and dexamethasone. During 2 years of follow-up, the patient has maintained a complete response for HL and a stable disease state for MM. The coexistence of HL and MM is rare. Further study of such cases may explain the associations between these two tumors and aid the production of effective treatment options.
霍奇金淋巴瘤（HL）是一种血液系统肿瘤，通常单发，发病率较低。大多数病例在组织病理学上表现为B细胞淋巴瘤。多发性骨髓瘤（MM）定义为产生单克隆免疫球蛋白（Ig）的单个浆细胞克隆的肿瘤性增殖。HL和MM并存的情况较为罕见，然而，本研究报告了这样一例病例。2012年5月31日，一名45岁男性在31个月前被诊断为III期HL。同时，计算机断层扫描和磁共振成像显示溶骨性病变、IgA λ链显著升高以及骨髓穿刺发现多发性骨髓瘤细胞。经过8个周期的化疗后，患者接受了沙利度胺和地塞米松的维持治疗。在2年的随访期间，患者的HL保持完全缓解，MM处于疾病稳定状态。HL和MM并存的情况较为罕见。对这类病例的进一步研究可能有助于解释这两种肿瘤之间的关联，并有助于制定有效的治疗方案。
