Ruoquan Yao, Wanpin Nie, Qiangsheng Xiao, Guodong Tian, Feizhou Huang
Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
J Int Med Res. 2014 Feb;42(1):77-84. doi: 10.1177/0300060513499093. Epub 2013 Nov 28.
This study aimed to define the correlation between microRNA-122 (miR-122) expression and hepatectomy-induced liver injury in patients with hepatocellular carcinoma (HCC).
Plasma miR-122 expression in patients with HCC and healthy age-matched controls was determined, and correlated with plasma alanine transaminase activity (ALT) and bilirubin levels preoperatively and on days 1 and 7 postoperation. Correlations between plasma miR-122 and clinicopathological characteristics at 1 day postoperation were also determined.
This study included 80 patients with HCC and 80 controls. Baseline expression of miR-122 mRNA and ALT in patients with HCC was significantly higher than in controls. MiR-122 expression correlated with ALT and bilirubin levels preoperatively and on days 1 and 7 postoperatively. In patients with HCC who received a block of the first hepatic portal during surgery and those with excised tumour size >5 cm, plasma miR-122 expression was significantly increased on day 1 postoperatively, compared with expression levels in those who did not receive a block and those with smaller tumours.
Plasma miR-122 expression is correlated with hepatectomy-induced liver injury in patients with HCC. Increase in miR-122 expression could be used as an index of such injury before and after hepatectomy in these patients.
本研究旨在明确微小RNA - 122（miR - 122）表达与肝细胞癌（HCC）患者肝切除术后肝损伤之间的相关性。
测定HCC患者及年龄匹配的健康对照者血浆中miR - 122的表达，并将其与术前、术后第1天和第7天的血浆丙氨酸转氨酶活性（ALT）及胆红素水平进行关联分析。同时还测定了术后第1天血浆miR - 122与临床病理特征之间的相关性。
本研究纳入80例HCC患者和80例对照者。HCC患者中miR - 122 mRNA和ALT的基线表达显著高于对照者。miR - 122表达与术前、术后第1天和第7天的ALT及胆红素水平相关。在手术中接受第一肝门阻断的HCC患者以及肿瘤切除大小>5 cm的患者中，术后第1天血浆miR - 122表达较未接受阻断及肿瘤较小的患者显著升高。
血浆miR - 122表达与HCC患者肝切除术后肝损伤相关。miR - 122表达升高可作为这些患者肝切除术前、后此类损伤的一个指标。
