Spasov A A, Kucheryavenko A F, Kosolapov V A, Anisimova V A
Department of Pharmacology, Volgograd State Medical University; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
Bull Exp Biol Med. 2013 Oct;155(6):775-7. doi: 10.1007/s10517-013-2250-x.
Antithrombotic activities of enoxifol, a new antioxidant with antiaggregant activity demonstrated in vitro and in vivo, and antioxidant mexidol were compared on the rat model of arterial thrombosis induced by application of 50% ferric chloride. Acetylsalicylic acid (antiaggregant) served as the reference drug. All drugs exhibited dose-dependent antithrombotic activity. Enoxifol was more effective than mexidol, both drugs being more active than the reference drug (acetylsalicylic acid). Taking into account the pathogenesis of the thrombosis in this experimental model, we can hypothesize that the pronounced antithrombotic effect of enoxifol was due to its antiaggregant and antioxidant activities.
在50%氯化铁诱导的大鼠动脉血栓形成模型上，比较了体外和体内均显示具有抗聚集活性的新型抗氧化剂烯氧昔酚及抗氧化剂美西多芬的抗血栓活性。乙酰水杨酸（抗聚集剂）作为参比药物。所有药物均呈现剂量依赖性抗血栓活性。烯氧昔酚比美西多芬更有效，两种药物均比参比药物（乙酰水杨酸）活性更强。考虑到该实验模型中血栓形成的发病机制，我们可以推测烯氧昔酚显著的抗血栓作用归因于其抗聚集和抗氧化活性。
