Kelly E, Nahorski S R
J Neurochem. 1986 Nov;47(5):1512-6. doi: 10.1111/j.1471-4159.1986.tb00787.x.
The ability of different receptors to mediate inhibition of cyclic AMP accumulation due to a variety of agonists was examined in rat striatal slices. In the presence of 1 mM 3-isobutyl-1-methylxanthine, dopamine D-2, muscarinic cholinergic, and opiate receptor stimulation by RU 24926, carbachol, and morphine (all at 10(-8)-10(-5) M), respectively, inhibited the increase in cyclic AMP accumulation in slices of rat striatum due to dopamine D-1 receptor stimulation by 1 microM SKF 38393. In contrast, these inhibitory agents were unable to reduce the ability of a number of other agonists, including isoprenaline, prostaglandin E1, 2-chloroadenosine, vasoactive intestinal polypeptide, and cholera toxin, to increase cyclic AMP levels in striatal slices. These results suggest that in rat striatum either dopamine D-2, muscarinic cholinergic, and opiate receptors are only functionally linked to dopamine D-1 receptors or that the D-1 and D-2 receptors linked to adenylate cyclase lie on the cells, distinct from other receptors capable of elevating striatal cyclic AMP levels.
在大鼠纹状体切片中检测了不同受体介导因多种激动剂导致的环磷酸腺苷（cAMP）积累抑制的能力。在存在1 mM 3 - 异丁基 - 1 - 甲基黄嘌呤的情况下，分别用RU 24926、卡巴胆碱和吗啡（均为10^(-8) - 10^(-5) M）刺激多巴胺D - 2、毒蕈碱胆碱能和阿片受体，抑制了因1 microM SKF 38393刺激大鼠纹状体切片中的多巴胺D - 1受体而导致的cAMP积累增加。相反，这些抑制剂无法降低包括异丙肾上腺素、前列腺素E1、2 - 氯腺苷、血管活性肠肽和霍乱毒素在内的许多其他激动剂在纹状体切片中增加cAMP水平的能力。这些结果表明，在大鼠纹状体中，要么多巴胺D - 2、毒蕈碱胆碱能和阿片受体仅在功能上与多巴胺D - 1受体相连，要么与腺苷酸环化酶相连的D - 1和D - 2受体位于细胞上，与其他能够提高纹状体cAMP水平的受体不同。
