Mattiucci Gian Carlo, Autorino Rosa, D'Agostino Giuseppe Roberto, Deodato Francesco, Macchia Gabriella, Perri Vincenzo, Tringali Andrea, Morganti Alessio Giuseppe, Mutignani Massimiliano, Valentini Vincenzo
Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
Crit Rev Oncol Hematol. 2014 Apr;90(1):58-67. doi: 10.1016/j.critrevonc.2013.10.007. Epub 2013 Nov 2.
To explore the role of radiotherapy in the extrahepatic bile duct carcinoma, and to understand if and when radiotherapy could be effective for this group of patients.
A systematic review of recently published literature was completed. Recent studies using radiotherapy with survival data, resection rates and quality of life data have been analyzed.
There are no randomized trials regarding the treatment of extrahepatic cholangiocarcinoma. The bulk of available studies suggest that in some cases radio-chemotherapy can be used as adjuvant therapy. Radiotherapy could also have a role in unresectable cholangiocarcinoma: external radiotherapy or intraluminal brachytherapy--alone or in combination--could improve the outcome in selected patients. Finally, radiotherapy, and in particular intraluminal brachytherapy, could be used as a palliative treatment to improve the quality of life and in controlling symptoms.
The role of radiotherapy in extrahepatic cholangiocarcinoma remains undefined due to the lack of randomized trials or otherwise properly controlled studies.
探讨放射治疗在肝外胆管癌中的作用，并了解放射治疗对该组患者是否有效以及何时有效。
完成了对近期发表文献的系统评价。分析了近期使用放射治疗并伴有生存数据、切除率和生活质量数据的研究。
尚无关于肝外胆管癌治疗的随机试验。大量现有研究表明，在某些情况下，放化疗可作为辅助治疗。放射治疗在无法切除的胆管癌中也可能发挥作用：外照射放疗或腔内近距离放疗——单独使用或联合使用——可改善部分患者的治疗效果。最后，放射治疗，特别是腔内近距离放疗，可作为姑息治疗手段来提高生活质量并控制症状。
由于缺乏随机试验或其他适当对照研究，放射治疗在肝外胆管癌中的作用仍不明确。
