Colomo N, Tapia M J, Vallejo M R, García-Torres F, Rubio-Martín E, Caballero F F, Jiménez J M, Pelaez M J, Gómez A M, Sánchez I, López-Siguero J P, Soriguer F, Ruiz de Adana M S
UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España; CIBER de diabetes y enfermedades metabólicas asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, España.
UGC de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, España.
An Pediatr (Barc). 2014 Sep;81(3):174-80. doi: 10.1016/j.anpedi.2013.09.007. Epub 2013 Nov 26.
To assess glycemic variability, oxidative stress and their relationship in children and adolescents with type 1 diabetes (T1DM) attending a summer camp.
Cross-sectional study that included 54 children and adolescents with T1DM aged 7-16, attending a 7 day summer camp. Sociodemographic information, clinical data, and blood glucose values measured using an Accu-Chek Nano® glucose meter were recorded. Glucose variability markers (standard deviation [SD], low blood glucose index [LBGI], high blood glucose index [HBGI], mean amplitude of glycemic excursions [MAGE] and mean of daily differences [MODD]) were calculated. Oxidative stress was assessed by the measurement of 8-iso-prostaglandin F2 alpha (PGF2α) in a 24-hour urine sample collected at the end of the camp in 14 children.
The Median SD, MAGE and MODD indexes were in the high range (61, 131 and 58 mg/dl, respectively), LBGI in the moderate range (3.3), and HBGI in the low range (4.5). The mean HbA1c was 7.6% and the median urinary excretion rate of 8-iso-PGF2α was 864.39 pg/mg creatinine. The Spearman correlation coefficients between markers of glycemic variability (SD, HBGI, MAGE, MODD) were significant. Non-significant correlations were found between markers of glycemic variability and urinary 8-iso-PGF2α.
High glycemic variability was observed in children and adolescents attending a summer camp. However, no correlations were found between markers of glycemic variability and oxidative stress measured by urinary 8-iso-PGF2α. Further studies are needed to address the relationship between oxidative stress and glycemic variability in children with T1DM.
评估参加夏令营的1型糖尿病（T1DM）儿童和青少年的血糖变异性、氧化应激及其关系。
横断面研究，纳入54名年龄在7至16岁、参加为期7天夏令营的T1DM儿童和青少年。记录社会人口学信息、临床数据以及使用罗氏卓越血糖仪测量的血糖值。计算血糖变异性指标（标准差[SD]、低血糖指数[LBGI]、高血糖指数[HBGI]、血糖波动幅度平均值[MAGE]和每日差异平均值[MODD]）。在夏令营结束时，对14名儿童收集的24小时尿液样本中测量8-异前列腺素F2α（PGF2α）以评估氧化应激。
SD、MAGE和MODD指数中位数处于较高范围（分别为61、131和58 mg/dl），LBGI处于中等范围（3.3），HBGI处于较低范围（4.5）。平均糖化血红蛋白（HbA1c）为7.6%，8-异PGF2α的尿排泄率中位数为864.39 pg/mg肌酐。血糖变异性指标（SD、HBGI、MAGE、MODD）之间的Spearman相关系数具有显著性。血糖变异性指标与尿8-异PGF2α之间未发现显著相关性。
参加夏令营的儿童和青少年中观察到高血糖变异性。然而，血糖变异性指标与通过尿8-异PGF2α测量的氧化应激之间未发现相关性。需要进一步研究以探讨T1DM儿童氧化应激与血糖变异性之间的关系。
