Velandia Arevalo J
J Cardiovasc Pharmacol. 1986;8 Suppl 3:S56-60. doi: 10.1097/00005344-198608003-00013.
Left ventricular mass and function were evaluated by M-mode echocardiography in 10 patients with essential hypertension, before and after 16 weeks of treatment with clonidine. Plasma renin activity (PRA), serum and 24-h urinary Na and K were also determined. The dose range of clonidine was 0.15-0.45 mg/day. Systolic and diastolic blood pressure decreased significantly since the second week of treatment (p less than 0.0001). There was a decrease in calculated total peripheral resistance (35.3 +/- 11.08 to 30.91 +/- 6.6 RU p less than 0.01), end meridional (72.9 +/- 23.6 to 58.5 +/- 22 dynes/cm2 X 10(3), p less than 0.001) and peak systolic wall stress (453.5 +/- 140 to 378 +/- 97 dynes/cm2 X 10(3), p less than 0.01), wall tension (333 +/- 36 to 286.6 +/- 42, p less than 0.01). Left ventricular mass index decreased in six patients (83.7 +/- 20.4 to 70.7 +/- 12.4 g/m2, p less than 0.001). Decrease in left ventricular mass index was related to decrease in wall tension (r = 0.70 p less than 0.01) and septal thickness in diastole (r = 0.71, p less than 0.01). There was a decrease in "double product" (10,934 +/- 1,975 to 8,705 +/- 1,739, p less than 0.01), PRA (3.74 +/- 2.51 to 2.51 +/- 1.44 ng/ml/h p less than 0.01) with increase in 24-h urinary Na (114.9 +/- 37 to 155.3 +/- 55.8 mEq/24-h urine, p less than 0.001). Cardiac index, left ventricular ejection fraction and fractional shortening increased without significance (p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
对10例原发性高血压患者在可乐定治疗16周前后，采用M型超声心动图评估左心室质量和功能。同时测定血浆肾素活性（PRA）、血清及24小时尿钠和钾。可乐定剂量范围为0.15 - 0.45毫克/天。自治疗第二周起收缩压和舒张压显著下降（p＜0.0001）。计算的总外周阻力下降（35.3±11.08至30.91±6.6 RU，p＜0.01），舒张末期内径（72.9±23.6至58.5±22达因/平方厘米×10³，p＜0.001）和收缩期峰值壁应力（453.5±140至378±97达因/平方厘米×10³，p＜0.01）、壁张力（333±36至286.6±42，p＜0.01）。6例患者左心室质量指数下降（83.7±20.4至70.7±12.4克/平方米，p＜0.001）。左心室质量指数下降与壁张力下降（r = 0.70，p＜0.01）和舒张期室间隔厚度下降（r = 0.71，p＜0.01）有关。“双乘积”下降（10,934±1,975至8,705±1,739，p＜0.01），PRA下降（3.74±2.51至2.51±1.44纳克/毫升/小时，p＜0.01），24小时尿钠增加（114.9±37至155.3±55.8毫当量/24小时尿，p＜0.001）。心脏指数、左心室射血分数和缩短分数增加但无显著性差异（p =无显著性）。（摘要截断于250字）
