Department of Bone and Soft Tissue Tumors, National Clinical Cancer Research Center, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China.
Department of Diagnostics, Tianjin Medical University, Tianjin 300060, China.
Eur J Cancer. 2014 Feb;50(3):593-601. doi: 10.1016/j.ejca.2013.11.006. Epub 2013 Nov 28.
Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.
癌组织中的间充质到上皮转化（MET）被提出可以在转移过程中促进上皮肿瘤细胞在远处生长。MET 也被认为是间充质肿瘤、肉瘤中的一个重要生物学和临床过程。在这里，我们回顾了关于肉瘤中 MET 的研究，包括分子标志物、信号机制、miRNA 调节以及治疗意义。越来越多的证据表明，对肉瘤中 MET 的深入研究和理解将揭示肉瘤的发病机制，并可能导致鉴定出潜在的用于预后的临床生物标志物和肉瘤治疗的靶点。
