Department of Surgery, University of Minnesota, 11-212 Moos Tower (Mail Code: MMC 195), 515 Delaware St, S.E, Minneapolis, MN 55455, USA.
Cell Mol Life Sci. 2012 Nov;69(21):3571-85. doi: 10.1007/s00018-012-1127-x. Epub 2012 Aug 25.
Sarcomas are a heterogeneous group of tumors with mesenchymal origins. Sarcomas are broadly classified into bone and soft tissue sarcomas with over 50 subtypes. Despite recent advances in sarcoma classification and treatment strategies, the prognosis of some aggressive sarcoma types remains poor due to treatment infectiveness and development of drug resistance. A better understanding of sarcoma pathobiology will significantly increase the potential for the development of therapeutics and treatment strategies. Recently, expressions of microRNAs (miRNA), a class of small non-coding RNAs, have been found to be deregulated in many sarcomas and are implicated in sarcoma pathobiology. Comprehensive understanding of gene regulatory networks mediated by miRNAs in each sarcoma type and the conservation of some shared/conserved miRNA-gene networks could be potentially investigated in the prevention, diagnosis, prognosis and as multi-modal treatment options in these cancers. In this review, we will discuss the current knowledge of miRNA-gene regulatory networks in various sarcoma types and give a perspective of the complex multilayer miRNA-mediated gene regulation in sarcomas.
肉瘤是一组具有间充质来源的异质性肿瘤。肉瘤广泛分为骨和软组织肉瘤，有 50 多种亚型。尽管肉瘤分类和治疗策略最近取得了进展，但由于治疗的感染性和耐药性的发展，一些侵袭性肉瘤类型的预后仍然较差。更好地了解肉瘤的病理生物学将显著增加治疗和治疗策略的发展潜力。最近，小 RNA（miRNA）的表达，一类小的非编码 RNA，已被发现失调在许多肉瘤，并参与肉瘤病理生物学。全面了解 miRNA 在每种肉瘤类型中介导的基因调控网络，以及一些共享/保守的 miRNA-基因网络的保守性，可能会在这些癌症的预防、诊断、预后和多模式治疗选择中得到研究。在这篇综述中，我们将讨论各种肉瘤类型中 miRNA-基因调控网络的现有知识，并对肉瘤中复杂的多层 miRNA 介导的基因调控进行展望。
