Huppertz Berthold, Ghosh Debabrata, Sengupta Jayasree
Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria.
Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
Prog Biophys Mol Biol. 2014 Jan;114(1):33-48. doi: 10.1016/j.pbiomolbio.2013.11.007. Epub 2013 Dec 1.
The placenta is an indispensable organ for intrauterine protection, development and growth of the embryo and fetus. It provides tight contact between mother and conceptus, enabling the exchange of gas, nutrients and waste products. The human placenta is discoidal in shape, and bears a hemo-monochorial interface as well as villous materno-fetal interdigitations. Since Peter Medawar's astonishment to the paradoxical nature of the mother-fetus relationship in 1953, substantial knowledge in the domain of placental physiology has been gathered. In the present essay, an attempt has been made to build an integrated understanding of morphological dynamics, cell biology, and functional aspects of genomic and proteomic expression of human early placental villous trophoblast cells followed by a commentary on the future directions of research in this field.
胎盘是胚胎和胎儿在子宫内进行保护、发育和生长所不可或缺的器官。它使母体与胎儿紧密相连，实现气体、营养物质及代谢废物的交换。人类胎盘呈盘状，具有血-单绒毛膜界面以及绒毛母胎相互交错的结构。自1953年彼得·梅达沃对母胎关系的矛盾本质感到惊讶以来，胎盘生理学领域已积累了大量知识。在本文中，我们试图对人类早期胎盘绒毛滋养层细胞的形态动力学、细胞生物学以及基因组和蛋白质组表达的功能方面形成综合理解，随后对该领域未来的研究方向进行评论。
