The crystal structure of LidA, a translocated substrate of the Legionella pneumophila type IV secretion system.
作者信息
Meng Geng, An Xiaojing, Ye Sheng, Liu Yong, Zhu Wenzhuang, Zhang Rongguang, Zheng Xiaofeng
机构信息
State Key Lab of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.
出版信息
Protein Cell. 2013 Dec;4(12):897-900. doi: 10.1007/s13238-013-2100-7.
Abstract
摘要
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Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state.结构洞察一种独特的军团菌效应物 LidA，可识别处于活性状态的 GDP 和 GTP 结合的 Rab1。
PLoS Pathog. 2012;8(3):e1002528. doi: 10.1371/journal.ppat.1002528. Epub 2012 Mar 1.
2
Protein LidA from Legionella is a Rab GTPase supereffector.来自军团菌的蛋白 LidA 是一种 Rab GTPase 的超级效应子。
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17945-50. doi: 10.1073/pnas.1113133108. Epub 2011 Oct 19.
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Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.宿主 Rab1 激活的结构机制由双歧杆科 IV 型效应物 SidM/DrrA 完成。
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4699-704. doi: 10.1073/pnas.0914231107. Epub 2010 Feb 22.
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Legionella pneumophila Dot/Icm translocated substrates: a sum of parts.嗜肺军团菌Dot/Icm转运底物：各部分之和
Curr Opin Microbiol. 2009 Feb;12(1):67-73. doi: 10.1016/j.mib.2008.12.004. Epub 2009 Jan 20.
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Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.Rab1鸟嘌呤核苷酸交换因子SidM是嗜肺军团菌的一种主要的磷脂酰肌醇4-磷酸结合效应蛋白。
J Biol Chem. 2009 Feb 20;284(8):4846-56. doi: 10.1074/jbc.M807505200. Epub 2008 Dec 17.
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A bifunctional bacterial protein links GDI displacement to Rab1 activation.一种双功能细菌蛋白将GDP解离抑制因子（GDI）的置换与Rab1激活联系起来。
Science. 2007 Nov 9;318(5852):974-7. doi: 10.1126/science.1149121. Epub 2007 Oct 18.
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The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.嗜肺军团菌LidA蛋白：一种与维持细菌完整性相关的Dot/Icm系统转运底物。
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