Bogusławska Joanna, Małecki Maciej
Department of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland, 0048 572-09-65,
Med Wieku Rozwoj. 2013 Jul-Sep;17(3):196-201.
Melanoma is a type of malignant skin cancer, characterized by a steadily increasing rate of morbidity, making it a continuous challenge for modern oncology. In recent years there has been a significant increase in developing gene therapy approaches for the treatment of cancer. The phenomenon of RNA interference initiated studies on the inhibition of the expression of selected genes by small interfering RNA (siRNA) in cells. The use of siRNA preparations for the treatment of patients depends on the transfection efficiency and the level of silencing the targeted genes. Currently, preclinical and clinical studies are being conducted in order to test the effectiveness and safety of siRNA preparations.
黑色素瘤是一种恶性皮肤癌，其发病率呈稳步上升趋势，这使其成为现代肿瘤学面临的持续挑战。近年来，用于癌症治疗的基因治疗方法有了显著增加。RNA干扰现象引发了关于细胞中小干扰RNA（siRNA）对特定基因表达抑制作用的研究。将siRNA制剂用于患者治疗取决于转染效率和靶向基因的沉默水平。目前，正在进行临床前和临床研究以测试siRNA制剂的有效性和安全性。
