Kowalska-Kańka Aneta, Maciejewski Tomasz, Niemiec Krzysztof Tomasz
Klinika Położnictwa i Ginekologii, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211 Warszawa, 0048 22 32-77-044,
Med Wieku Rozwoj. 2013 Jul-Sep;17(3):270-5.
Although erythropoietin plays a significant role in human metabolism, relatively little attention has been devoted in scientific literature to its role and mechanisms regulating its secretion in pregnancy. The authors of this article discussed the following issues: - construction, biological role and regulation of erythropoietin secretion, - its extra-hematologic effect, - erythropoietin concentration in normal and complicated pregnancy, - erythropoietin secretion in placenta, including its effect on placental function, - the role of erythropoietin in evaluation of fetal well-being. What seems to be a particularly promising trend in further studies is popularizing the measurement of EPO concentration in cord blood or amniotic fluid as fetal hypoxia marker.
尽管促红细胞生成素在人体新陈代谢中发挥着重要作用，但科学文献中相对较少关注其在妊娠期间的作用及其分泌调节机制。本文作者讨论了以下问题：- 促红细胞生成素的结构、生物学作用及其分泌调节；- 其血液外效应；- 正常妊娠和合并症妊娠时促红细胞生成素的浓度；- 胎盘促红细胞生成素的分泌，包括其对胎盘功能的影响；- 促红细胞生成素在评估胎儿健康状况中的作用。在进一步研究中，一个特别有前景的趋势似乎是推广将脐血或羊水促红细胞生成素浓度作为胎儿缺氧标志物进行检测。
