De Lima M E, Martin M F, Diniz C R, Rochat H
Biochem Biophys Res Commun. 1986 Aug 29;139(1):296-302. doi: 10.1016/s0006-291x(86)80112-7.
Some beta-toxins from the South American scorpion Tityus serrulatus (e.g. Ts VII) are highly toxic both for mouse and fly larva. Radioiodinated Ts VII and the insect toxin from the North African scorpion Androctonus australis Hector (AaH IT) bind to the same site on a house fly head synaptosomal fraction. These results reinforce the hypothesis about the existence of a correlated series of scorpion toxins as previously defined by amino acid compositions and sequences, and immunological and circular dichroism studies, in suggesting that Ts VII constitutes a link which may fill the pharmacological gap existing between beta-toxins and insect toxins such as AaH IT.
一些来自南美锯齿蝎（Tityus serrulatus）的β毒素（如Ts VII）对小鼠和果蝇幼虫都具有高毒性。放射性碘化的Ts VII和来自北非蝎子黄肥尾蝎（Androctonus australis Hector）的昆虫毒素（AaH IT）与家蝇头部突触体组分上的同一位点结合。这些结果强化了关于存在一系列相关蝎子毒素的假说，正如先前通过氨基酸组成和序列、免疫学及圆二色性研究所定义的那样，这表明Ts VII构成了一个可能填补β毒素和诸如AaH IT等昆虫毒素之间存在的药理学空白的环节。
