疟原虫的比较基因组学与系统生物学
Comparative Genomics and Systems Biology of Malaria Parasites .
作者信息
Cai Hong, Zhou Zhan, Gu Jianying, Wang Yufeng
机构信息
Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA.
出版信息
Curr Bioinform. 2012 Dec 1;7(4). doi: 10.2174/157489312803900965.
Abstract
Malaria is a serious infectious disease that causes over one million deaths yearly. It is caused by a group of protozoan parasites in the genus . No effective vaccine is currently available and the elevated levels of resistance to drugs in use underscore the pressing need for novel antimalarial targets. In this review, we survey omics centered developments in biology, which have set the stage for a quantum leap in our understanding of the fundamental processes of the parasite life cycle and mechanisms of drug resistance and immune evasion.
摘要
疟疾是一种严重的传染病，每年导致超过一百万人死亡。它由属的一组原生动物寄生虫引起。目前尚无有效的疫苗，且正在使用的药物耐药性水平不断升高，凸显了对新型抗疟靶点的迫切需求。在本综述中，我们概述了生物学中以组学为中心的进展，这些进展为我们在理解寄生虫生命周期的基本过程、耐药机制和免疫逃避机制方面实现巨大飞跃奠定了基础。
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