胚胎干细胞中的转化生长因子-β家族信号传导
Tgf-Beta family signaling in embryonic stem cells.
作者信息
Park Kyung-Soon
机构信息
Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.
出版信息
Int J Stem Cells. 2011 Jun;4(1):18-23. doi: 10.15283/ijsc.2011.4.1.18.
Abstract
Ligands of transforming growth factor beta (TGF-β) family members have been implicated in the development and patho-physiological process of various organs. Embryonic stem cells (ESCs) are characterized by their ability to proliferate indefinitely and differentiated into all three germ layer cells, which are termed as pluripotency and self-renewal,respectively. For successful therapeutic application of ESCs, it is essential to understand the mechanisms underlying self-renewal and pluripotency, which involve complex networks among key factors including transcription factors, epigenetic control, microRNAs and signaling pathways. In this review, we discuss recent progress on the function of TGF beta family ligands and their canonical SMAD signaling in the maintenance of ESC' s identity.
摘要
转化生长因子β（TGF-β）家族成员的配体已被证明参与了各种器官的发育和病理生理过程。胚胎干细胞（ESC）的特点是能够无限增殖并分化为所有三个胚层的细胞，这分别被称为多能性和自我更新。为了使ESC成功应用于治疗，了解自我更新和多能性的潜在机制至关重要，这涉及转录因子、表观遗传控制、微小RNA和信号通路等关键因素之间的复杂网络。在这篇综述中，我们讨论了TGF-β家族配体及其经典SMAD信号在维持ESC特性方面的功能的最新进展。
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1
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Int J Stem Cells. 2010 May;3(2):129-37. doi: 10.15283/ijsc.2010.3.2.129.
2
Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling.
Stem Cells. 2010 Sep;28(9):1498-509. doi: 10.1002/stem.479.
3
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.
Cell Stem Cell. 2009 Nov 6;5(5):491-503. doi: 10.1016/j.stem.2009.09.012. Epub 2009 Oct 8.
4
Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc.
Curr Biol. 2009 Nov 3;19(20):1718-23. doi: 10.1016/j.cub.2009.08.025. Epub 2009 Sep 17.
5
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression.
Development. 2009 Apr;136(8):1339-49. doi: 10.1242/dev.033951. Epub 2009 Mar 11.
6
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs.
Cell Stem Cell. 2008 Aug 7;3(2):196-206. doi: 10.1016/j.stem.2008.07.001.
7
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.
Cell Stem Cell. 2008 May 8;2(5):497-507. doi: 10.1016/j.stem.2008.03.008.
8
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.
Cell Stem Cell. 2008 Jan 10;2(1):72-82. doi: 10.1016/j.stem.2007.10.022.
9
Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.
Stem Cells. 2008 Apr;26(4):874-85. doi: 10.1634/stemcells.2007-0608. Epub 2008 Jan 31.
10
BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling.
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