BF3·乙醚盐介导的 2-羟基-1,4-苯并恶嗪的Friedel-Crafts 芳基化反应：2-芳基-1,4-苯并恶嗪衍生物的合成。
BF3·etherate-mediated Friedel-Crafts arylation of 2-hydroxy-1,4-benzoxazines: synthesis of 2-aryl-1,4-benzoxazine derivatives.
机构信息
Department of Chemistry, Indian Institute of Technology , Roorkee-247667, Uttarakhand, India.
出版信息
J Org Chem. 2013 Dec 20;78(24):12819-24. doi: 10.1021/jo402254n. Epub 2013 Dec 3.
PMID:24299014
Abstract
BF3·etherate-mediated carbon-carbon bond formation by the Friedel-Crafts arylation of 2-hydroxybenzoxazine derivatives with various electron-rich arenes is reported. The current protocol provides an easy access for the synthesis of a series of densely substituted 2-aryl-1,4-benzoxazine derivatives under mild conditions.
摘要
报道了 BF3·乙醚盐介导的 2-羟基苯并恶嗪衍生物与各种富电子芳环的 Friedel-Crafts 芳基化碳-碳键形成。该现行方案在温和条件下为合成一系列稠取代的 2-芳基-1,4-苯并恶嗪衍生物提供了一种简便的方法。
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