Tsuruo T, Hamilton T C, Louie K G, Behrens B C, Young R C, Ozols R F
Jpn J Cancer Res. 1986 Sep;77(9):941-5.
Three cell lines resistant to adriamycin, melphalan and cisplatin were established in vitro from human ovarian cancer cell line A2780. Each subline showed a resistance to its inducing drug of 75-fold in the case of adriamycin, 6-fold in the case of melphalan and 11-fold in the case of cisplatin. However, all of these sublines showed collateral sensitivity to bleomycin. Approximately a 2-fold higher susceptibility to bleomycin was observed generally. The biochemical mechanisms of this collateral sensitivity are not clear at present, but the higher concentration of glutathione in these resistant tumor cell lines might be related to the high susceptibility of these resistant cells to bleomycin.
从人卵巢癌细胞系A2780体外建立了三种对阿霉素、美法仑和顺铂耐药的细胞系。每个亚系对其诱导药物的耐药性分别为：阿霉素75倍、美法仑6倍、顺铂11倍。然而，所有这些亚系对博来霉素均表现出协同敏感性。一般观察到对博来霉素的敏感性大约高2倍。目前这种协同敏感性的生化机制尚不清楚，但这些耐药肿瘤细胞系中较高浓度的谷胱甘肽可能与这些耐药细胞对博来霉素的高敏感性有关。
