Department of Anesthesia, Yenimahalle State Hospital, Ankara, Turkey.
Eur Rev Med Pharmacol Sci. 2013 Nov;17(22):3019-3023.
Sevoflurane is an ideal agent for anesthesia since its respiratory irritant effect is minimal during mask induction. Emergence agitation (EA) is a common problem after anesthesia with sevoflurane. In this study it was aimed to compare the effects of dexmedetomidine and remifentanyl on emergence agitation after sevoflurane anesthesia in adults undergoing septoplasty operation.
This prospective, randomized, double-blind study was conducted in Yenimahalle State Hospital after obtaining local Ethics Committee approval and patient's written informed consent. The patients were randomized into dexmedetomidine and remifentanyl groups. Hemodynamic parameters including heart rat, Mean arterial pressure, and sPO2 were recorded. The patients were followed for 1 hour at the recovery room. Categorical data was analyzed using c2 test. Hemodynamic data was evaluated using unpaired t test for intergroup and paired t-test for within group comparisons. Data not normally distributed was compared using Mann Whitney U test. p < 0.05 was considered statistically significant.
Demographic data were similar in both groups (p > 0.05). Riker score was similar in both groups. VAS score was also not significantly different between both groups at the recovery room.
Our study demonstrated that Dexmedotimidine and Remifentanyl had equal effectiveness in reducing emergence agitation in patients undergoing septoplasty under Sevoflurane anesthesia.
七氟醚是一种理想的麻醉剂，因为在面罩诱导期间，它的呼吸刺激性最小。七氟醚麻醉后苏醒期躁动（EA）是一个常见的问题。本研究旨在比较右美托咪定和瑞芬太尼对行鼻中隔成形术的成年人在七氟醚麻醉后苏醒期躁动的影响。
本前瞻性、随机、双盲研究在获得当地伦理委员会批准和患者书面知情同意后，在 Yenimahalle 州立医院进行。患者随机分为右美托咪定和瑞芬太尼组。记录包括心率、平均动脉压和 sPO2 在内的血流动力学参数。患者在恢复室观察 1 小时。使用 c2 检验分析分类数据。使用配对 t 检验比较组内比较，使用独立样本 t 检验比较组间血流动力学数据。非正态分布的数据采用 Mann-Whitney U 检验进行比较。p<0.05 为统计学显著。
两组患者的人口统计学数据相似（p>0.05）。两组的 Riker 评分相似。两组患者在恢复室的 VAS 评分也无显著差异。
我们的研究表明，右美托咪定和瑞芬太尼在减少行鼻中隔成形术的患者在七氟醚麻醉后苏醒期躁动方面同样有效。
