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Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse.

作者信息

Ferraro T N, Golden G T, DeMattei M, Hare T A, Fariello R G

出版信息

Neuropharmacology. 1986 Sep;25(9):1071-4. doi: 10.1016/0028-3908(86)90205-4.

DOI:10.1016/0028-3908(86)90205-4
PMID:2430229
Abstract

Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.

摘要

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