Bevan J A, Buga G M, Moskowitz M A, Said S I
Neuroscience. 1986 Oct;19(2):597-604. doi: 10.1016/0306-4522(86)90284-8.
Experiments have been undertaken to determine the nature of the atropine-resistant neurogenic dilation that can be demonstrated in vitro in cephalic arteries of the cat. Levels of vasoactive intestinal peptide (VIP) and substance P were measured in a number of arteries and related to the extent of the neurogenic dilation that can be elicited in vitro. There is no correlation between the tissue contents of the two peptides. A positive correlation was found between vasoactive intestinal peptide but not substance P content and neurogenic dilation. Vasoactive intestinal peptide but not substance P consistently caused a concentration-dependent dilation of cephalic arteries not subject to significant tachyphylaxis. Vasoactive intestinal peptide antiserum in concentrations that block the dilation to vasoactive intestinal peptide (10(-6) M) but not that due to papaverine, significantly reduced neurodilation of both atropinized and non-atropinized lingual arteries--the cephalic artery with the highest VIP content. These results suggest that vasoactive intestinal peptide and not substance P significantly contributes to the non-cholinergic neurogenic dilation observed in vitro in arterial segments from the head of the cat.
已开展实验以确定在猫的头部动脉体外实验中可表现出的对阿托品耐药的神经源性扩张的性质。在一些动脉中测量了血管活性肠肽（VIP）和P物质的水平，并将其与体外可引发的神经源性扩张程度相关联。这两种肽的组织含量之间没有相关性。发现血管活性肠肽而非P物质的含量与神经源性扩张之间存在正相关。血管活性肠肽而非P物质持续引起头部动脉浓度依赖性扩张，且不存在明显快速耐受性。能阻断对血管活性肠肽扩张作用（10(-6) M）但不阻断因罂粟碱引起扩张作用的浓度的血管活性肠肽抗血清，显著降低了阿托品化和未阿托品化舌动脉（VIP含量最高的头部动脉）的神经源性扩张。这些结果表明，血管活性肠肽而非P物质在体外猫头部动脉段观察到的非胆碱能神经源性扩张中起显著作用。
