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血管活性肠肽和神经源性刺激对绵羊脑动脉的舒张作用：L-NG-单甲基精氨酸对去内皮血管的抑制作用

Relaxation of sheep cerebral arteries by vasoactive intestinal polypeptide and neurogenic stimulation: inhibition by L-NG-monomethyl arginine in endothelium-denuded vessels.

作者信息

Gaw A J, Aberdeen J, Humphrey P P, Wadsworth R M, Burnstock G

机构信息

Department of Physiology & Pharmacology, University of Strathclyde, Glasgow.

出版信息

Br J Pharmacol. 1991 Mar;102(3):567-72. doi: 10.1111/j.1476-5381.1991.tb12213.x.

DOI:10.1111/j.1476-5381.1991.tb12213.x
PMID:1364820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917941/
Abstract
  1. Perivascular nerves of the sheep middle cerebral artery show immunoreactivity for both vasoactive intestinal polypeptide (VIP) and calcitonin gene-related peptide (CGRP). 2. Rings of endothelium-denuded sheep middle cerebral artery precontracted with 5-hydroxytryptamine were relaxed by CGRP (maximum relaxation = 87.8 +/- 8.1%, pD2 = 7.81 +/- 0.12, n = 12) and by VIP (maximum relaxation = 55.1 +/- 4.1%, pD2 = 7.65 +/- 0.04, n = 18). Rings of endothelium-denuded cat middle cerebral artery precontracted with U46619 were also relaxed by vasoactive intestinal polypeptide (maximum relaxation = 53.1 +/- 6.1%, pD2 = 7.82 +/- 0.11, n = 6). 3. Haemolysate (1 microliters ml-1) inhibited VIP-induced relaxation in endothelium-denuded sheep and cat middle cerebral artery (n = 6) but had no effect on the CGRP-induced relaxation of the sheep middle cerebral artery (n = 6). 4. The relaxant response to VIP in endothelium-denuded sheep middle cerebral artery was inhibited by methylene blue (10 microM) and augmented by either M&B 22948 (10 microM) or superoxide dismutase (150 units ml-1). Indomethacin (1 microM) had no effect. 5. The addition of L-NG-monomethyl arginine (100 microM) inhibited both neurogenic and VIP-induced relaxation of endothelium-denuded sheep MCA by 56 +/- 6% and 60 +/- 6% (n = 5) respectively. The CGRP-induced relaxation was unaffected. 6. It is concluded that neurally mediated vasodilatation in the sheep middle cerebral artery is mediated largely by VIP through a direct action on smooth muscle through a cyclic-GMP-mediated mechanism that appears to involve synthesis of nitric oxide from L-arginine. Vasodilatation by CGRP, which is also contained in perivascular nerves, does not utilize this pathway.
摘要
  1. 绵羊大脑中动脉的血管周围神经对血管活性肠肽（VIP）和降钙素基因相关肽（CGRP）均显示免疫反应性。2. 用5-羟色胺预收缩的去内皮绵羊大脑中动脉环，CGRP可使其舒张（最大舒张率 = 87.8 +/- 8.1%，pD2 = 7.81 +/- 0.12，n = 12），VIP也可使其舒张（最大舒张率 = 55.1 +/- 4.1%，pD2 = 7.65 +/- 0.04，n = 18）。用U46619预收缩的去内皮猫大脑中动脉环，血管活性肠肽也可使其舒张（最大舒张率 = 53.1 +/- 6.1%，pD2 = 7.82 +/- 0.11，n = 6）。3. 溶血产物（1微升/毫升）抑制去内皮绵羊和猫大脑中动脉中VIP诱导的舒张（n = 6），但对绵羊大脑中动脉中CGRP诱导的舒张无影响（n = 6）。4. 去内皮绵羊大脑中动脉对VIP的舒张反应被亚甲蓝（10微摩尔）抑制，被M&B 22948（10微摩尔）或超氧化物歧化酶（150单位/毫升）增强。吲哚美辛（1微摩尔）无影响。5. 添加L-NG-单甲基精氨酸（100微摩尔）分别抑制去内皮绵羊大脑中动脉神经源性和VIP诱导的舒张56 +/- 6%和60 +/- 6%（n = 5）。CGRP诱导的舒张不受影响。6. 得出结论，绵羊大脑中动脉神经介导的血管舒张主要由VIP介导，通过对平滑肌的直接作用，通过环磷酸鸟苷介导的机制，该机制似乎涉及从L-精氨酸合成一氧化氮。血管周围神经中也含有的CGRP介导的血管舒张不利用此途径。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/1917941/c4d94560cbd1/brjpharm00242-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/1917941/c4d94560cbd1/brjpharm00242-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/1917941/c4d94560cbd1/brjpharm00242-0024-a.jpg

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VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals.哺乳动物颅内动脉中含血管活性肠肽（VIP）的神经。
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