动态度和定量磁化率：脑海绵状血管畸形的相关成像生物标志物。
Dynamic permeability and quantitative susceptibility: related imaging biomarkers in cerebral cavernous malformations.
机构信息
From the Section of the Neurosurgery (A.G.M., H.T., R.S., L.L., L.Z., C.S., I.A.), Brain Research Imaging Center (X.G.), and Section of Neuroradiology, Department of Diagnostic Radiology (A.S., G.C.), The University of Chicago, IL; Department of Neurosurgery, West China Hospital of Sichuan University, Sichuan, China (L.L.); MedImageMetric LLC, New York, NY (T.L.); Department of Radiology, Weill Cornell Medical College, New York, NY (Y.W.); Department of Biomedical Engineering, Cornell University, Ithaca, NY (Y.W.); Department of Radiology, NorthShore University HealthSystem, Evanston, IL (R.R.E.); Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL (R.R.E.); Functional Imaging Unit, Department of Diagnostics, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark (H.B.W.L.); and Department of Circulation and Medical Imaging, The Norwegian University of Technology and Science, Trondheim, Norway (H.B.W.L.).
出版信息
Stroke. 2014 Feb;45(2):598-601. doi: 10.1161/STROKEAHA.113.003548. Epub 2013 Dec 3.
BACKGROUND AND PURPOSE
Hyperpermeability and iron deposition are 2 central pathophysiological phenomena in human cerebral cavernous malformation (CCM) disease. Here, we used 2 novel MRI techniques to establish a relationship between these phenomena.
METHODS
Subjects with CCM disease (4 sporadic and 17 familial) underwent MRI imaging using the dynamic contrast-enhanced quantitative perfusion and quantitative susceptibility mapping techniques that measure hemodynamic factors of vessel leak and iron deposition, respectively, previously demonstrated in CCM disease. Regions of interest encompassing the CCM lesions were analyzed using these techniques.
RESULTS
Susceptibility measured by quantitative susceptibility mapping was positively correlated with permeability of lesions measured using dynamic contrast-enhanced quantitative perfusion (r=0.49; P≤0.0001). The correlation was not affected by factors, including lesion volume, contrast agent, and the use of statin medication. Susceptibility was correlated with lesional blood volume (r=0.4; P=0.0001) but not with lesional blood flow.
CONCLUSIONS
The correlation between quantitative susceptibility mapping and dynamic contrast-enhanced quantitative perfusion suggests that the phenomena of permeability and iron deposition are related in CCM; hence, more leaky lesions also manifest a more cumulative iron burden. These techniques might be used as biomarkers to monitor the course of this disease and the effect of therapy.
背景与目的
高通透性和铁沉积是人类脑海绵状血管畸形（CCM）疾病的两个中心病理生理现象。在这里，我们使用两种新的 MRI 技术来建立这两种现象之间的关系。
方法
4 例散发性和 17 例家族性 CCM 疾病患者接受了 MRI 成像，使用动态对比增强定量灌注和定量磁化率映射技术，分别测量血管通透性和铁沉积的血流动力学因素，这些方法在 CCM 疾病中已有证实。使用这些技术对包含 CCM 病变的感兴趣区域进行分析。
结果
定量磁化率映射测量的磁化率与动态对比增强定量灌注测量的病变通透性呈正相关（r=0.49；P≤0.0001）。这种相关性不受病变体积、造影剂和他汀类药物使用等因素的影响。磁化率与病变内血容量（r=0.4；P=0.0001）相关，但与病变内血流量无关。
结论
定量磁化率映射和动态对比增强定量灌注之间的相关性表明，通透性和铁沉积现象在 CCM 中是相关的；因此，更易漏的病变也表现出更累积的铁负荷。这些技术可作为监测该疾病过程和治疗效果的生物标志物。
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