Tsutsumi Yutaka, Yamamoto Yoshiya, Shimono Joji, Ohhigashi Hiroyuki, Teshima Takanori
Yutaka Tsutsumi, Joji Shimono, Hiroyuki Ohhigashi, Department of Hematology, Hakodate Municipal Hospital, Minato-cho, Hakodate 041-8680, Japan.
World J Hepatol. 2013 Nov 27;5(11):612-20. doi: 10.4254/wjh.v5.i11.612.
Rituximab is recognized as a useful drug for the treatment of B-cell non-Hodgkin's lymphoma and its use has been extended to such diseases as idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, chronic rheumatoid arthritis and ANCA-associated vasculitides. One serious complication associated with its use is the reactivation of hepatitis B virus and the search for methods to prevent this occurrence has resulted in the rapid accumulation of knowledge. In this review, we discuss case analyses from our department and other groups and outline the current knowledge on the topic and the remaining issues.
利妥昔单抗被认为是治疗B细胞非霍奇金淋巴瘤的有效药物,其应用已扩展到特发性血小板减少性紫癜、血栓性血小板减少性紫癜、慢性类风湿性关节炎和抗中性粒细胞胞浆抗体相关性血管炎等疾病。与使用该药相关的一种严重并发症是乙型肝炎病毒再激活,而对预防这种情况发生的方法的探索导致了知识的迅速积累。在本综述中,我们讨论了我们科室和其他团队的病例分析,并概述了该主题的现有知识和遗留问题。