I Wahid Fazal, Fawad Khan Sahibzada, Ur Rehman Habib, Ahmad Khan Iftikhar
Department of otorhinolaryngology, Post Graduate Medical Institute, Peshawar, Khyber Pakhtunkhwa Pakistan.
Iran J Otorhinolaryngol. 2011 Fall;23(65):111-8.
This study was conducted at the Department of ear, nose, throat, head and neck surgery, Post Graduate Medical Institute Lady Reading Hospital Peshawar. The duration of the study was one year from June 17, 2009 to June 16, 2010. The sample size was 82 patients with solitary thyroid nodule, fulfilling the inclusion criteria. After taking detailed history, thorough examination, relevant investigation and informed consent fine needle aspiration cytology was performed in all cases by the same cytopathologist. Thyroid surgery was performed and specimens were examined by the same histopathologist. The statistical analysis was performed using the statistical program for social sciences (SPSS version 11).
Our study included 82 cases consisting on 57 female and 25 male, with female: male ratio of 2.28: 1.The age of the patients was ranged from 16-65 years with mean age of 42.56 + S.D 11.60 years. Most of the patients presented in 3(rd) and 4(th) decade followed by the 5(th) and 2(nd) decade. The diagnostic yield of Fine Needle Aspiration Cytology (FNAC) in this study was accuracy 82.92%, sensitivity 88.09%, specificity 77.50% and positive predictive value was 80.43%.
One hundred twenty six patients entered the study among which 77 (61%) were female and 49 (39%) male. Mean age was obtained as 26.9 ± 7.7 yrs. Up to 79.4% of patients had complaints concerning the cosmetic outcomes, 39.7% with respiratory and 4.8% with olfactory problems. The reason to sue the physician had a significant relationship with the patients' age and sex, and also with the surgeons' experience.
FNAC has key rule in diagnosis of solitary thyroid nodule because it is safe, minimally invasive and cost effective diagnostic tool.
本研究在白沙瓦市莱迪·里德医院研究生医学研究所耳鼻喉头颈外科进行。研究为期一年，从2009年6月17日至2010年6月16日。样本量为82例符合纳入标准的孤立性甲状腺结节患者。在详细询问病史、全面检查、进行相关检查并获得知情同意后，由同一位细胞病理学家对所有病例进行细针穿刺细胞学检查。进行甲状腺手术，标本由同一位组织病理学家检查。使用社会科学统计程序（SPSS 11版）进行统计分析。
我们的研究包括82例患者，其中女性57例，男性25例，女性与男性比例为2.28:1。患者年龄在16 - 65岁之间，平均年龄为42.56±标准差11.60岁。大多数患者出现在第三和第四十年龄段，其次是第五和第二十年龄段。本研究中细针穿刺细胞学检查（FNAC）的诊断准确率为82.92%，敏感性为88.09%，特异性为77.50%，阳性预测值为80.43%。
126例患者进入研究，其中77例（61%）为女性，49例（39%）为男性。平均年龄为26.9±7.7岁。高达79.4%的患者有关于美容效果的主诉，39.7%有呼吸问题，4.8%有嗅觉问题。起诉医生的原因与患者的年龄、性别以及外科医生的经验有显著关系。
FNAC在孤立性甲状腺结节的诊断中起关键作用，因为它是一种安全、微创且经济有效的诊断工具。
