在草酸钙微石形成过程中肝素硫酸的产生。

Production of heparan sulfate in the process of calcium oxalate microlith formation.

机构信息

Department of Urology, Ehime University School of Medicine, Ehime, Japan.

出版信息

Int J Urol. 1996 Jan;3(1 Suppl):S69-71. doi: 10.1111/j.1442-2042.1996.tb00092.x.

DOI:10.1111/j.1442-2042.1996.tb00092.x

Abstract

To evaluate the interaction in the renal tubules between calcium oxalate microliths and glycosaminoglycans, especially heparan sulfate, we planned an experimentally-induced calcium oxalate microlith-producing model in rats. We found by immunofluorescence study and immunoelectron microscopy using the heparan sulfate antibody that heparan sulfate was produced in the renal tubular cells in the formation of calcium oxalate microliths and that heparan sulfate exists in the microliths. Heparan sulfate/crystal interaction might play a role as a nucleating agent and promote stone enlargement.

摘要

为了评估草酸钙微石和糖胺聚糖（尤其是硫酸乙酰肝素）在肾小管中的相互作用，我们计划在大鼠中建立一个实验性草酸钙微石产生模型。通过免疫荧光研究和使用硫酸乙酰肝素抗体的免疫电镜观察，我们发现硫酸乙酰肝素是在草酸钙微石形成过程中由肾小管细胞产生的，并且存在于微石中。硫酸乙酰肝素/晶体相互作用可能作为成核剂发挥作用，并促进结石增大。