*Ophthalmology Department, La Fe University Hospital †Ophthalmology Department, Medicine Faculty, Catholic University of Valencia §Ophthalmology Department, Medicine Faculty, University of Valencia ‡Research Center for Rare Diseases (CIBERER), Valencia, Spain.
J Glaucoma. 2013 Dec;22(9):750-6. doi: 10.1097/IJG.0b013e318264ba4d.
Tissue adhesives have been used in ophthalmology instead of sutures to minimize the operating time. This case series investigated the effectiveness and safety of use of cyanoacrylate in Ahmed valve implantation through pars plana for refractory glaucoma.
Seventeen eyes of 17 patients with refractory glaucoma underwent Ahmed valve scleral suture-less implantation through pars plana with a cyanoacrylate suture of the plate. Refractory glaucoma was defined as intraocular pressure (IOP) ≥ 21 mm Hg with antiglaucoma eye drops, good adherence to treatment, and no previous glaucoma surgery. IOP control and development of complications were evaluated during the follow-up (mean follow-up, 13.23 mo, 6 to 28 mo).
IOP control, defined as IOP ≤ 21 mm Hg with or without antiglaucoma eye drops, was achieved in 82.2% of patients, and 58.8% were able to eliminate antiglaucoma eye drops. Mean surgical time was 9.76 ± 2.60 and 6 ± 0.81 minutes in patients with previous vitrectomy (4 cases). Postoperative complications included transiently increased IOP, transient hyphema, early postoperative hypotony (4 cases), and tube block by the vitreous (2 cases): 1 resolved by Nd:YAG and the other by second vitrectomy. No cases of tube or plate extrusion, plate migration, choroidal or retinal detachment, or vitreous hemorrhage were observed.
These results are promising and demonstrate a safe and effective alternative to the traditional scleral suture. Our data suggest that Ahmed valve implantation through pars plana with cyanoacrylate is a safe and effective method for refractory glaucoma. Further studies are needed to confirm our observation.
组织粘合剂已被用于眼科,以代替缝线,从而缩短手术时间。本病例系列研究了通过睫状体平坦部使用氰基丙烯酸酯对 Ahmed 阀进行无巩膜缝线植入术治疗难治性青光眼的效果和安全性。
17 例(17 只眼)难治性青光眼患者接受了 Ahmed 阀巩膜无缝线经睫状体平坦部植入术,并用氰基丙烯酸酯固定阀板。难治性青光眼的定义为眼压(IOP)≥21mmHg,尽管使用了降眼压眼药水,但治疗依从性良好,且之前未行青光眼手术。在随访期间(平均随访时间为 13.23 个月,6 至 28 个月)评估眼压控制情况和并发症的发生情况。
82.2%的患者眼压控制(定义为眼压≤21mmHg,或需联合使用降眼压眼药水),58.8%的患者可停用降眼压眼药水。有玻璃体切割术史(4 例)的患者手术时间平均为 9.76±2.60 分钟,无玻璃体切割术史(13 例)的患者手术时间平均为 6±0.81 分钟。术后并发症包括一过性眼压升高、一过性前房积血、早期低眼压(4 例)和玻璃体管阻塞(2 例):1 例通过 Nd:YAG 激光治疗缓解,另 1 例通过第二次玻璃体切割术治疗缓解。未观察到管或阀板脱出、阀板移位、脉络膜或视网膜脱离或玻璃体积血等并发症。
这些结果令人鼓舞,表明通过睫状体平坦部使用氰基丙烯酸酯替代传统的巩膜缝线是一种安全有效的方法。我们的数据表明,通过睫状体平坦部使用氰基丙烯酸酯行 Ahmed 阀植入术治疗难治性青光眼是一种安全有效的方法。需要进一步的研究来证实我们的观察结果。