载药能力超高的聚丙烯酸@沸石咪唑酯骨架-8 纳米粒子用于 pH 敏感药物释放。
Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release.
机构信息
Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.
出版信息
Chem Commun (Camb). 2014 Jan 28;50(8):1000-2. doi: 10.1039/c3cc47666a.
PMID:24306285
Abstract
The polyacrylic acid@zeolitic imidazolate framework-8 (PAA@ZIF-8) nanoparticles (NPs) were first fabricated using a facile and simple route. It is worthwhile noting that the as-fabricated PAA@ZIF-8 NPs possessed ultrahigh doxorubicin (DOX) loading capability (1.9 g DOX g(-1) NPs), which were employed as pH-dependent drug delivery vehicles.
摘要
聚丙烯酸@沸石咪唑酯骨架-8（PAA@ZIF-8）纳米粒子（NPs）首先通过一种简便的方法制备。值得注意的是，所制备的 PAA@ZIF-8 NPs 具有超高阿霉素（DOX）负载能力（1.9 g DOX g（-1）NPs），可用作 pH 依赖性药物输送载体。
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