Microbiology Department, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK.
Expert Rev Mol Diagn. 2014 Jan;14(1):47-54. doi: 10.1586/14737159.2014.864238. Epub 2013 Dec 2.
Serum procalcitonin (PCT) is an established diagnostic marker for severe or systemic bacterial infections such as pneumonia, sepsis and septic shock. Data regarding the role of PCT in localized infections without systemic inflammatory response syndrome are scarce. The aim of this review is to assess the value of PCT measurements in localized infections such as skin and skin structure infections, diabetic foot infections, septic arthritis (SA) and osteomyelitis. It appears that serum PCT is unlikely to change the clinical practice in skin and skin structure infection. However, serum PCT could have a role in diagnosis and monitoring of diabetic foot infections in hospitalized settings. There are conflicting reports regarding the ability of serum PCT to distinguish SA from non-SA; synovial PCT may be more appropriate in these settings, including in implant-related infections. Better designed studies are needed to evaluate the usefulness of PCT with or without other biomarkers in localized infections.
降钙素原（PCT）是一种已被证实的用于诊断严重或全身性细菌感染的标志物，如肺炎、败血症和感染性休克。关于 PCT 在没有全身炎症反应综合征的局部感染中的作用的数据还很有限。本综述的目的是评估 PCT 测量在局部感染（如皮肤和皮肤结构感染、糖尿病足感染、化脓性关节炎（SA）和骨髓炎）中的价值。似乎 PCT 血清水平不太可能改变皮肤和皮肤结构感染的临床实践。然而，在住院环境中，PCT 血清水平可能在诊断和监测糖尿病足感染方面发挥作用。关于 PCT 血清水平能否区分 SA 和非 SA 的能力存在相互矛盾的报告；关节液 PCT 可能更适合这些情况，包括与植入物相关的感染。需要更好设计的研究来评估 PCT 与其他生物标志物联合或不联合在局部感染中的有用性。
