Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
J Integr Plant Biol. 2013 Dec;55(12):1264-70. doi: 10.1111/jipb.12122.
Plants utilize plasma membrane-localized receptor-like kinases (RLKs) to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co-receptor of several distinct ligand-binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid (BR) signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRI1. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling. [Figure: see text] Jia Li (Corresponding author).
植物利用定位于质膜的受体样激酶（RLKs）来感知细胞外信号，以协调生长、发育和先天免疫反应。BAK1 作为几种不同配体结合 RLK 的共受体，调节多种信号通路。一直存在争议的是，BAK1 是作为一个必需的调节成分，还是只是一个没有途径特异性的信号放大器。这个问题最近已经得到澄清。遗传和结构分析表明，BAK1 及其同源物在直接感知配体 BR 和激活 BR 受体 BRI1 来介导油菜素内酯（BR）信号通路中发挥不可或缺的作用。这些研究揭示的机制现在为一对 RLK 如何在配体结合和随后的信号起始中协同作用提供了一个范例。[图：见正文] Jia Li（Corresponding author）。
