Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Division of Plant Sciences, School of Life Sciences, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA, UK.
Plant Commun. 2020 Apr 24;1(4):100050. doi: 10.1016/j.xplc.2020.100050. eCollection 2020 Jul 13.
The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant pathogen. Here, we review intracellular effectors from filamentous (fungal and oomycete) phytopathogens and the host proteins and processes that are targeted to promote disease. We cover contrasting virulence strategies and effector modes of action. Filamentous pathogen effectors alter the fates of host proteins that they target, changing their stability, their activity, their location, and the protein partners with which they interact. Some effectors inhibit target activity, whereas others enhance or utilize it, and some target multiple host proteins. We discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support susceptibility. We also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens, including those representing different kingdoms of life.
能够分泌可进入植物细胞并操纵宿主进程的效应蛋白是决定成功的植物病原体的关键因素。在这里，我们回顾了丝状（真菌和卵菌）植物病原体的细胞内效应物以及被靶向以促进疾病的宿主蛋白和过程。我们涵盖了对比鲜明的毒力策略和效应物作用模式。丝状病原体效应物改变它们靶向的宿主蛋白的命运，改变其稳定性、活性、位置以及与其相互作用的蛋白伴侣。一些效应物抑制靶标活性，而另一些则增强或利用它，还有一些靶标多个宿主蛋白。我们讨论了针对免疫负调节剂或其他具有支持易感性的活性的植物蛋白的效应物这一新兴主题。我们还强调了被来自多种病原体的效应物操纵的常见靶标宿主蛋白，包括那些代表不同生命王国的蛋白。
