Vijayamurugan Nataraj, Bakhshi Sameer
Departments of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi-110029, India.
Expert Rev Anticancer Ther. 2014 Feb;14(2):151-61. doi: 10.1586/14737140.2014.863453. Epub 2013 Nov 26.
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. With combined modality treatment long-term survival rate for localized disease is near 70%. Thirty percent of patients relapse with lung as the commonest site. Surgery is the treatment of choice for relapsed patients whenever possible. Addition of chemotherapy to surgery provides survival benefit in patients not achieving second surgical remission. Even patients with multiple lung recurrences can be cured with repeated thoracotomies. Disease-free interval and complete surgical resection are the main prognostic factor for post-relapse survival.
骨肉瘤是儿童和青少年中最常见的原发性恶性骨肿瘤。采用综合治疗，局限性疾病的长期生存率接近70%。30%的患者会复发，最常见的复发部位是肺部。只要有可能，手术是复发患者的首选治疗方法。对于未实现第二次手术缓解的患者，手术加化疗可提高生存率。即使是有多次肺部复发的患者，通过反复开胸手术也可治愈。无病间期和完全手术切除是复发后生存的主要预后因素。
