Furqan Muhammad, Akinleye Akintunde, Mukhi Nikhil, Mittal Varun, Chen Yamei, Liu Delong
Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA.
J Hematol Oncol. 2013 Dec 5;6:90. doi: 10.1186/1756-8722-6-90.
Signal Transducer and Activator of Transcription (STAT) proteins are a family of cytoplasmic transcription factors consisting of 7 members, STAT1 to STAT6, including STAT5a and STAT5b. STAT proteins are thought to be ideal targets for anti-cancer therapy since cancer cells are more dependent on the STAT activity than their normal counterparts. Inhibitors targeting STAT3 and STAT5 have been developed. These included peptidomimetics, small molecule inhibitors and oligonucleotides. This review summarized advances in preclinical and clinical development of these compounds.
信号转导与转录激活因子（STAT）蛋白是一类细胞质转录因子家族，由7个成员组成，即STAT1至STAT6，包括STAT5a和STAT5b。由于癌细胞比正常细胞更依赖于STAT活性，因此STAT蛋白被认为是抗癌治疗的理想靶点。目前已开发出靶向STAT3和STAT5的抑制剂，包括拟肽、小分子抑制剂和寡核苷酸。本文综述了这些化合物在临床前和临床开发方面的进展。
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