Zerah L, Brochériou I, Galichon P, Peltier J, Hertig A
Urgences néphrologiques et transplantation rénale, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.
Anatomie-pathologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; UPMC Sorbonne Universités, 75006 Paris, France.
Rev Med Interne. 2015 Jan;36(1):51-4. doi: 10.1016/j.revmed.2013.09.006. Epub 2013 Dec 3.
Warfarin-related nephropathy (WRN) is a newly recognized entity, which is characterized by the occlusion of renal tubules by red blood cells following glomerular hemorrhage in a patient overexposed to warfarin (international normalized ratio>3).
We report a 70-year-old man with no previous renal condition who developed WRN when his INR was>12. He did not fully recover his previous renal function.
The diagnosis of WRN should be considered whenever INR exceeds 3 in patients exposed to warfarin, particularly in the presence of hematuria. Vitamin K is the only therapeutic option.
华法林相关肾病（WRN）是一种新认识的疾病实体，其特征为服用华法林过量（国际标准化比值>3）的患者肾小球出血后肾小管被红细胞阻塞。
我们报告一名既往无肾脏疾病的70岁男性，其国际标准化比值>12时发生了WRN。他未完全恢复到之前的肾功能。
对于服用华法林的患者，只要国际标准化比值超过3，尤其是存在血尿时，就应考虑WRN的诊断。维生素K是唯一的治疗选择。
