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本文引用的文献

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Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide.一种神经细胞表面抗原的组织和发育阶段特异性形式，与一种共同多肽的糖基化差异相关。
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Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.从胚胎脑膜中纯化的神经细胞黏附分子的化学特性分析。
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Binding properties of a cell adhesion molecule from neural tissue.一种来自神经组织的细胞黏附分子的结合特性。
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Enzyme-linked immunosorbent assay of the D2-glycoprotein.D2糖蛋白的酶联免疫吸附测定
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Mapping the fodrin molecule with monoclonal antibodies. A general approach for rod-like multidomain proteins.
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Occurrence of alpha 2-8 linked polysialosyl units in a neural cell adhesion molecule.神经细胞黏附分子中α2-8连接的多唾液酸基元的出现。
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Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.成年鸡和胚胎鸡大脑中神经细胞黏附分子碳水化合物结构的差异。
J Biol Chem. 1982 Sep 25;257(18):11064-9.
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Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. The use of liposome-inserted radioiodinated N-CAM to study its transbilayer orientation.神经细胞黏附分子N-CAM的跨膜分布研究。利用脂质体插入放射性碘化N-CAM研究其跨双层取向。
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Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. A monoclonal antibody recognizing a cytoplasmic domain and evidence for the presence of phosphoserine residues.神经细胞黏附分子N-CAM跨膜定位的研究。一种识别胞质结构域的单克隆抗体及磷酸丝氨酸残基存在的证据。
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Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.神经细胞黏附分子胚胎型和成年型的同源性结合动力学
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N-细胞黏附分子结构与功能决定因素的拓扑学。II. 单克隆抗体表位的定位

Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopes.

作者信息

Frelinger A L, Rutishauser U

出版信息

J Cell Biol. 1986 Nov;103(5):1729-37. doi: 10.1083/jcb.103.5.1729.

DOI:10.1083/jcb.103.5.1729
PMID:2430977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2114365/
Abstract

The accompanying report (Watanabe, M., A. L. Frelinger III, and U. Rutishauser, 1986, J. Cell Biol., 103:1721-1727) describes a set of monoclonal antibodies (mAbs) directed against N-CAM epitopes representing the known major structural and functional domains of the molecule. In this study, we have generated and separated a variety of peptide fragments from N-CAM, and then used their size and reactivity with each antibody to position the antigenic sites along the peptide chain. This epitope map, together with the biological properties of the antibodies and previous studies on N-CAM, have been used to construct a topographical model for the molecule in the cell membrane.

摘要

随附报告（渡边，M.，A.L.弗莱林格三世，和U.鲁蒂沙伊泽，1986年，《细胞生物学杂志》，103:1721 - 1727）描述了一组针对神经细胞黏附分子（N - CAM）表位的单克隆抗体（mAb），这些表位代表了该分子已知的主要结构和功能域。在本研究中，我们从N - CAM中生成并分离出了多种肽片段，然后利用它们的大小以及与每种抗体的反应性来确定抗原位点在肽链上的位置。这个表位图谱，连同抗体的生物学特性以及先前对N - CAM的研究，已被用于构建细胞膜中该分子的拓扑模型。