Department of Genetics, Harvard Medical School, 02114, Boston, MA, USA.
Photosynth Res. 1994 Mar;39(3):427-38. doi: 10.1007/BF00014596.
Although feedback regulation of photosynthesis by carbon metabolites has long been recognized and investigated, its underlying molecular mechanisms remain unclear. The recent discovery that glucose and acetate trigger global repression of maize photosynthetic gene transcription provides the first direct evidence that a fundamental mechanism is used for feedback regulation of photosynthesis in higher plants. The metabolic repression of photosynthetic genes has now been found in many higher plants and is likely universal. It overrides other regulation by light, tissue type and developmental stage, and serves potentially as the molecular basis of interactions between sink and source tissues. Using simplified and convenient cellular systems and transgenic plants, the study of metabolic regulation of gene expression offers an excellent opportunity for the understanding of global and coordinate gene control and metabolite-mediated signal transduction in higher plants.
尽管碳代谢物对光合作用的反馈调节早已被认识和研究，但其中的分子机制仍不清楚。最近发现，葡萄糖和醋酸盐触发了玉米光合作用基因转录的全局抑制，这为高等植物光合作用的反馈调节使用一种基本机制提供了首个直接证据。在许多高等植物中，现已发现了光合作用基因的代谢抑制，这种抑制很可能是普遍存在的。它超越了光、组织类型和发育阶段的其他调节，并且可能是作为源和汇组织之间相互作用的分子基础。利用简化和方便的细胞体系和转基因植物，对基因表达的代谢调控的研究为理解高等植物中的全局和协调基因控制以及代谢物介导的信号转导提供了极好的机会。
