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Long-term outcome of genital reconstruction of Middle Eastern women with congenital adrenal hyperplasia.

作者信息

Seyam Raouf M, Bissada Nabil K, Abdul-Aaly Mohamed, Sakati Nadia A, Al Taweel Waleed, Alkhudair Waleed K

机构信息

Department of Urology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia ; Department of Urology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

出版信息

Urol Ann. 2013 Oct;5(4):277-82. doi: 10.4103/0974-7796.120308.

Abstract

OBJECTIVES

There is a paucity of data on the long-term outcome of genital reconstruction of female children with congenital adrenal hyperplasia (CAH) as they become adult women. We report on the surgical outcome general condition and marriage status.

MATERIALS AND METHODS

We reviewed the medical records of women 20 years or older with CAH who had genital reconstruction. We interviewed married patients utilizing the female sexual function index (FSFI-6) questionnaire and compared them to age-matched controls.

RESULTS

We identified 43 women with CAH with a median age of 24.2 ± 3.9 years and a median follow-up of 23.4 ± 4.6 years. Salt wasting and the severity of virilization affected most patients, parents were commonly cousins, children were reared as boys for a protracted period and surgical reconstruction was usually complex. Only five women had married. Compared with single women, married women had significantly more frequent normal menses, emergency hospital admissions and number of repeated reconstructive surgery. There was no significant difference in FSFI score between patients and controls. Four women conceived and three gave birth to one healthy child. There was no significant difference in the number of children between patients and controls.

CONCLUSIONS

CAH has a significant impact on adult women in our region. Most of the patients remain single. Few women get married and these are able to lead a nearly normal sexual life and give birth to healthy children.

摘要

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本文引用的文献

1
UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development.
Clin Endocrinol (Oxf). 2011 Jul;75(1):12-26. doi: 10.1111/j.1365-2265.2011.04076.x.
2
Sexual function and attitudes toward surgery after feminizing genitoplasty.
J Urol. 2011 May;185(5):1900-4. doi: 10.1016/j.juro.2010.12.099.
3
Individual comparisons of grouped data by ranking methods.
J Econ Entomol. 1946 Apr;39:269. doi: 10.1093/jee/39.2.269.
4
Surgical options in disorders of sex development (dsd) with ambiguous genitalia.
Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):311-24. doi: 10.1016/j.beem.2009.10.004.
7
Gender assignment and hormonal treatment for disorders of sexual differentiation.
Pediatr Surg Int. 2008 Oct;24(10):1131-5. doi: 10.1007/s00383-008-2232-7.
8
Fertility and pregnancy outcome in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Hum Reprod. 2008 Jul;23(7):1607-13. doi: 10.1093/humrep/den118. Epub 2008 Apr 16.
9
Sexual function and genital sensitivity following feminizing genitoplasty for congenital adrenal hyperplasia.
J Urol. 2008 Feb;179(2):634-8. doi: 10.1016/j.juro.2007.09.079. Epub 2007 Dec 21.
10
Type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia.
J Clin Endocrinol Metab. 2008 Feb;93(2):380-6. doi: 10.1210/jc.2007-0556. Epub 2007 Nov 20.

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