癌症：复制起点的参与？

Cancer: involvement of replicative origins?

作者信息

Grossgebauer K

出版信息

Med Hypotheses. 1986 Oct;21(2):127-40. doi: 10.1016/0306-9877(86)90002-2.

Abstract

The assumption is made that movable genetic elements related to cancer are replicons and/or replicative origins. Some evidence is provided that certain mobile Alu-origins may represent candidates for precursors of chromosomal insertions. They could incorporate and interact with "fixed" chromosomal origins converting them to "procaryotic" ones. In other words, cancer is considered the result of a short and compact "re-evolution" from eucaryotic to "procaryotic" replication units.

摘要

有一种假设认为，与癌症相关的可移动遗传元件是复制子和/或复制起点。有证据表明，某些可移动的Alu起源可能是染色体插入前体的候选者。它们可以整合到“固定”的染色体起点中并与其相互作用，将其转化为“原核”起点。换句话说，癌症被认为是从真核复制单位到“原核”复制单位的短暂而紧凑的“重新进化”的结果。