Maghsoodi Maryam, Derakhshandeh Katayoun, Yari Zahra
Drug applied Research Center and School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2012;2(1):25-30. doi: 10.5681/apb.2012.004. Epub 2012 Feb 15.
Agglomeration in suspension is a size enlargement method that facilitates operation of solid processing and preserves the solubilization properties of fine particles. A small quantity of binder liquid is added into a suspension of microparticles, directly in the stirred vessel where the precipitation or crystallization took place. This study deals with the evaluation of the effect of agitation time before and after addition of binder liquid on agglomerates properties in order to give some insights into the mechanism of the formation of the agglomerates.
Carbamazepine is used as a model drug and isopropyl acetate is used as binder liquid. The agglomerates characterization includes the particle size, morphology and density.
The results showed that, by increasing the agitation time before addition of binder liquid, smaller agglomerates with less density and irregular forms composed of larger crystals were obtained. However, with increasing agitation time after addition of binder liquid the agglomerates size and density increases and morphology improves. Indeed, by continuing agitation along the course of agglomeration the properties of the particles change gradually but substantially.
With optimized agitation time before and after addition of binder liquid, spherical and dense agglomerates can be obtained.
悬浮液中的团聚是一种增大颗粒尺寸的方法，它便于固体加工操作并保留细颗粒的溶解特性。将少量粘合剂液体直接添加到微粒悬浮液中，就在发生沉淀或结晶的搅拌容器内。本研究旨在评估添加粘合剂液体前后的搅拌时间对团聚体性质的影响，以便深入了解团聚体的形成机制。
以卡马西平为模型药物，乙酸异丙酯为粘合剂液体。团聚体表征包括粒度、形态和密度。
结果表明，增加添加粘合剂液体前的搅拌时间，可得到由较大晶体组成的密度较小、形状不规则的较小团聚体。然而，增加添加粘合剂液体后的搅拌时间，团聚体尺寸和密度会增加，形态会改善。实际上，在团聚过程中持续搅拌，颗粒的性质会逐渐但显著地发生变化。
通过优化添加粘合剂液体前后的搅拌时间，可以获得球形且致密的团聚体。
