某些含噻唑部分的新型芳基腙吡唑啉-5-酮的合成、表征及抗菌活性
Synthesis, characterization and antimicrobial activity of certain novel aryl hydrazone pyrazoline-5-ones containing thiazole moiety.
作者信息
Reddy Maliki Reddy Dastagiri, Prasad Aluru Raghavendra Guru, Spoorthy Yadati Narasimha, Ravindranath Lakshmana Rao Krishna Rao
机构信息
Sri Krishnadevaraya University, Anantapur, A.P., India.
出版信息
Adv Pharm Bull. 2013;3(1):153-9. doi: 10.5681/apb.2013.026. Epub 2013 Feb 7.
Abstract
PURPOSE
The aim of this article is to synthesize, characterize and evaluate the antimicrobial activity of certain novel 3-methyl-5-oxo-4-(phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid N|-(4-substituted thiazol-2-yl)-hydrazides.
METHODS
The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. The antimicrobial activity of novel compounds was evaluated by broth dilution method.
RESULTS
XVe, XVf and XVg have shown better antibacterial activity than other compounds of the series. XVa, XVc, XVd and XVe have shown better antifungal activity than the other compounds of the series.
CONCLUSION
All compounds were found to exhibit fair degree of antimicrobial activity.
摘要
目的
本文旨在合成、表征并评估某些新型3-甲基-5-氧代-4-（苯腙基）-4,5-二氢吡唑-1-基]乙酸N|-(4-取代噻唑-2-基)-酰肼的抗菌活性。
方法
通过元素分析以及红外、核磁共振和质谱数据对合成的化合物进行表征。采用肉汤稀释法评估新型化合物的抗菌活性。
结果
XVe、XVf和XVg表现出比该系列其他化合物更好的抗菌活性。XVa、XVc、XVd和XVe表现出比该系列其他化合物更好的抗真菌活性。
结论
发现所有化合物均表现出一定程度的抗菌活性。
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