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某些新型噻唑的合成与抗菌评估

Synthesis and antimicrobial evaluation of certain novel thiazoles.

作者信息

Sreedevi Meesaraganda, Guru Prasad Aluru Raghavendra, Spoorthy Yadati Narasimha, Ravindranath Lakshmana Rao Krishna Rao

机构信息

Sri Krishnadevaraya Univerisity, Anantapur, Andhra Pradesh, India.

出版信息

Adv Pharm Bull. 2013;3(1):227-30. doi: 10.5681/apb.2013.037. Epub 2013 Feb 7.

DOI:10.5681/apb.2013.037
PMID:24312840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3846066/
Abstract

PURPOSE

This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties.

METHODS

The novel compounds synthesized were characterized by elemental analysis, IR and (1)HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method.

RESULTS

The compound p-t showed more antibacterial activity than that of the standard. p-hp and p-as showed considerable antibacterial activity. p-t demonstrated higher antifungal activity than that of the standard while p-hp and p-as showed considerable antifungal activity.

CONCLUSION

The antimicrobial activity studies were conducted on certain selected bacteria and fungi. In each case antimicrobial activity of the compounds was compared with that of standards. p-t, p-hp, p-np, p-cp, p-ts and p-as showed considerable antimicrobial activity.

摘要

目的

本文尝试合成某些含有噻唑和咪唑部分的化合物，并筛选其抗菌性能。

方法

通过元素分析、红外光谱和核磁共振氢谱（HNMR）数据对合成的新型化合物进行表征。采用杯碟法评估新型化合物的抗菌活性。

结果

化合物p-t的抗菌活性比标准品更高。p-hp和p-as表现出相当的抗菌活性。p-t的抗真菌活性高于标准品，而p-hp和p-as表现出相当的抗真菌活性。

结论

对某些选定的细菌和真菌进行了抗菌活性研究。在每种情况下，将化合物的抗菌活性与标准品进行比较。p-t、p-hp、p-np、p-cp、p-ts和p-as表现出相当的抗菌活性。

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Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs.合成、抗菌及某些新型咪唑类似物的潜在抗 HIV 活性。
Acta Pharm. 2011 Jun;61(2):187-201. doi: 10.2478/v10007-011-0018-2.
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Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents.2-氨基-1-芳亚氨基咪唑的合成及生物活性作为口服有效的抗癌药物。
J Med Chem. 2010 Mar 25;53(6):2409-17. doi: 10.1021/jm901501s.
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Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring.含 2,4-二取代噻唑环的新型席夫碱的合成、抑菌和抗真菌活性。
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Poly(ethylene glycol) (PEG-400) as an alternative reaction solvent for the synthesis of some new 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazolines and their in vitro antimicrobial evaluation.聚乙二醇（PEG-400）作为一种替代反应溶剂，用于合成一些新型的 1-(4-(4'-氯苯基)-2-噻唑基)-3-芳基-5-(2-丁基-4-氯-1H-咪唑-5-基)-2-吡唑啉，并对其进行了体外抗菌评价。
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