Sharpe L G, Jaffe J H
Neurosci Lett. 1986 Nov 11;71(2):213-8. doi: 10.1016/0304-3940(86)90561-6.
Rats received injections of either capsaicin (50 mg/kg, s.c.) or the capsaicin vehicle at two days of age. When the animals were 90-120 days of age they were implanted with morphine or placebo pellets (s.c.) for 3 (one pellet) or 6 (3 pellets) days. Naloxone (0.4 mg/kg, s.c.) produced no effects in the placebo-pelleted groups but elicited salivation, lacrimation and rhinorrhea in the morphine-treated animals. These abstinence signs were less severe in the morphine-pelleted rats (3- and 6-day groups) that were treated as neonates with capsaicin. However, the neonatal capsaicin treatment increased the number of naloxone-precipitated wet-dog shakes in morphine-dependent rats. The increase was statistically significant in rats treated with morphine for 3 but not 6 days. Since capsaicin induces a long-lasting depletion of substance P and other peptides in peripheral and central neurons, it was concluded that substance P or other related peptides may be involved in the expression of some signs of opioid withdrawal.
新生大鼠在出生两天时接受辣椒素（50毫克/千克，皮下注射）或辣椒素溶媒注射。当动物90至120日龄时，给它们皮下植入吗啡或安慰剂药丸3天（一粒药丸）或6天（三粒药丸）。纳洛酮（0.4毫克/千克，皮下注射）对接受安慰剂药丸的组没有影响，但在接受吗啡治疗的动物中引发了流涎、流泪和流涕。在新生期接受辣椒素治疗的吗啡药丸处理大鼠（3天和6天组）中，这些戒断症状较轻。然而，新生期辣椒素治疗增加了吗啡依赖大鼠中纳洛酮诱发的湿狗样抖动次数。在用吗啡治疗3天而非6天的大鼠中，这种增加具有统计学意义。由于辣椒素会导致外周和中枢神经元中P物质和其他肽类的长期耗竭，因此得出结论，P物质或其他相关肽类可能参与了阿片类药物戒断某些症状的表达。
