Guentsch A, Pfister W, Cachovan G, Raschke G, Kuepper H, Schaefer O, Eick S
Policlinic of Prosthetic Dentistry and Material Science, Jena University Hospital - Friedrich Schiller University, Jena, Germany; Marquette University School of Dentistry, Milwaukee, WI, USA.
Int J Dent Hyg. 2014 Aug;12(3):199-207. doi: 10.1111/idh.12063. Epub 2013 Dec 7.
A controlled clinical trial was conducted to evaluate the effects of oral prophylaxis on halitosis-associated, immunological and microbiological parameters.
Thirty subjects were included in this controlled clinical trial (patients with generalized chronic periodontitis and controls without clinical attachment loss; each n = 15). Before oral prophylaxis and 14 days after (including tongue cleaning) volatile sulphur compounds (VSC), organoleptic scores and a tongue coating index were evaluated. The levels of IL-1β, IL-8, IL-10 and MMP-8 were measured in GCF, and also major periodontal pathogens were detected. Data were statistically analysed using anova and paired t-test.
Supragingival plaque and calculus removal with combined tongue cleaning was able to reduce significantly (P < 0.05) the VSC values in both groups (no significant differences between both groups). Two weeks after periodontal debridement, the VSC values were observed in the periodontitis group, but not in the control group, similar to the baseline values. The difference between the groups was statistically significant (P < 0.05). Only a repeated prophylaxis session in the periodontitis group was able to reduce VSC values significantly in comparison with baseline (P < 0.05). Organoleptic scores (10 and 30 cm) were significantly different (P < 0.05) between both groups before and after the treatment. Periodontal pathogens and host-derived markers were not significantly affected by a single prophylaxis session.
Oral prophylaxis may result in a significant decrease in VSC values. However, in periodontal diseases, a more complex treatment seems to be necessary.
开展一项对照临床试验，以评估口腔预防措施对与口臭相关的、免疫学和微生物学参数的影响。
30名受试者纳入了这项对照临床试验（患有广泛性慢性牙周炎的患者和无临床附着丧失的对照组；每组n = 15）。在进行口腔预防措施前以及14天后（包括舌清洁），评估挥发性硫化物（VSC）、感官评分和舌苔指数。测量龈沟液中白细胞介素-1β（IL-1β）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）和基质金属蛋白酶-8（MMP-8）的水平，并且检测主要的牙周病原体。使用方差分析和配对t检验对数据进行统计学分析。
联合舌清洁清除龈上菌斑和牙石能够显著降低（P < 0.05）两组的VSC值（两组之间无显著差异）。牙周清创术后两周，牙周炎组观察到VSC值，而对照组未观察到，与基线值相似。两组之间的差异具有统计学意义（P < 0.05）。与基线相比，仅牙周炎组重复进行预防措施能够显著降低VSC值（P < 0.05）。治疗前后两组的感官评分（10和30 cm）存在显著差异（P < 0.05）。单一的预防措施对牙周病原体和宿主来源标志物没有显著影响。
口腔预防措施可能会使VSC值显著降低。然而，在牙周疾病中，似乎需要更复杂的治疗。
