Prada Garcia Camino, Sanchez Sambucety Pedro, Rodriguez Prieto Manuel Ángel
Complejo Asistencial Universitario de Leon.
Dermatol Online J. 2013 Nov 15;19(11):20408.
Leukemia cutis refers to cutaneous infiltration by malignant hematopoietic cells. Its clinical manifestations are highly variable and biopsy is required for confirmation. We present three cases of patients with persistent monocytosis and skin lesions whose diagnosis was chronic myelomonocytic leukemia. The biopsy of skin lesions showed a dermal infiltration by atypical myelocytes and monocytes. Immunohistochemical study was positive for CD68. These findings were compatible with cutaneous infiltration by chronic myelomonocytic leukemic cells.
皮肤白血病是指恶性造血细胞浸润皮肤。其临床表现高度多变，确诊需要活检。我们报告了3例持续性单核细胞增多症和皮肤病变患者，其诊断为慢性粒单核细胞白血病。皮肤病变活检显示真皮有非典型骨髓细胞和单核细胞浸润。免疫组织化学研究显示CD68呈阳性。这些发现与慢性粒单核细胞白血病细胞的皮肤浸润相符。
