Virdi I S, Monro J L, Ross J K
Thorac Cardiovasc Surg. 1986 Oct;34(5):277-82. doi: 10.1055/s-2007-1022154.
Aortic valve replacement with an antibiotic-treated aortic valve homograft was performed in 200 patients between April 1973 and December 1984. In all cases, a two-layered freehand technique of valve implantation was used. Tailoring of the annulus was performed in 39 cases and a gusset in the non-coronary sinus was used to maintain the shape of the aortic root in 67 patients. There were 6 early deaths (3%) and 14 late deaths (7.2%); 4 of these were related to homograft regurgitation. The 11 years survival rate on actuarial analysis was 83%. The overall incidence of early diastolic murmurs was 27.3%; being significantly higher in those with tailored roots (P less than 0.001). Severe homograft aortic valve incompetence requiring re-operation developed in 3.1%. Anticoagulant therapy was not used routinely, and there was no major thromboembolic episode in those who had isolated homograft aortic valve replacement. There was one case of miliary tuberculosis but pyogenic and fungal endocarditis were not encountered. No hemolysis, valvular calcification or stenosis was observed.
1973年4月至1984年12月期间，200例患者接受了经抗生素处理的主动脉瓣同种异体移植主动脉瓣置换术。所有病例均采用两层徒手瓣膜植入技术。39例进行了瓣环修整，67例在无冠状窦使用角撑板以维持主动脉根部的形状。早期死亡6例（3%），晚期死亡14例（7.2%）；其中4例与同种异体移植反流有关。经精算分析，11年生存率为83%。舒张早期杂音的总体发生率为27.3%；在根部修整的患者中显著更高（P小于0.001）。3.1%的患者出现严重的同种异体移植主动脉瓣关闭不全需要再次手术。未常规使用抗凝治疗，单纯同种异体移植主动脉瓣置换的患者未发生重大血栓栓塞事件。有1例粟粒性结核，但未遇到化脓性和真菌性心内膜炎。未观察到溶血、瓣膜钙化或狭窄。
