Marente V Camacho, Gomez L M Marin, Martinez J Gracia, Bernal-Bellido C, Suárez-Artacho G, Alamo-Martínez J M, Barrera-Pulido L, Serrano-Díaz-Canedo J, Padillo-Ruiz F J, Gómez-Bravo M A
Hepatobiliopancreatic Surgery Unit, General and Digestive Surgery, Virgen del Rocío University Hospitals, Seville, Spain.
Transplant Proc. 2013;45(10):3670-1. doi: 10.1016/j.transproceed.2013.09.018.
We report our experience with a 61-year-old patient with alcoholic and hepatitis C cirrhosis who underwent liver transplantation. On the 3rd postoperative day he presented a mediastinitis secondary to esophageal perforation produced by a Linton tube. An esophagectomy with jejunostomy was performed. Tacrolimus granules for oral suspension (Modigraf) were administered through the jejunostomy. This case report highlights the use of Modigraf and the absence of secondary effects. We observed biochemical parameters during the jejunostomy period. We discuss the administration strategy applied and whether tacrolimus granules for oral suspension by jejunostomy affect the bioavailability and its side effects.
我们报告了一位61岁酒精性和丙型肝炎肝硬化患者接受肝移植的经验。术后第3天，他出现了由林顿管导致的食管穿孔继发纵隔炎。进行了食管切除术并做空肠造口术。通过空肠造口术给予口服混悬液他克莫司颗粒（Modigraf）。本病例报告强调了Modigraf的使用及无副作用。我们在空肠造口术期间观察了生化指标。我们讨论了所应用的给药策略以及空肠造口术给予口服混悬液他克莫司颗粒是否会影响生物利用度及其副作用。
