蛋白稳态失调：阿尔茨海默病与糖尿病的交汇点。
Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes.
机构信息
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
出版信息
Cell Metab. 2013 Dec 3;18(6):771-2. doi: 10.1016/j.cmet.2013.11.009.
Altered insulin signaling and neuroinflammation are emerging features of Alzheimer's disease. Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.
胰岛素信号改变和神经炎症是阿尔茨海默病的新特征。Lourenco 等人（2013 年）确定了一种在阿尔茨海默病和糖尿病之间共享的致病机制，该机制通过一个共同的分子事件导致记忆丧失：PKR 对蛋白质合成的控制和 eIF2α 的下游磷酸化。
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